I assume(d) that the OP and others were thinking of purpose-designed race V6s ie 3 crank throws, not road-related V6s
(that these days have a configuration that functions as 6 crank throws, however called)
In the 60s etc we had (in production by accident) both the Ferrari/Fiat 65 deg 3 throw engines (from front-engined F2/1 use), and 90 deg 3 throw engines from Buick, Honda and Renault/Peugeot/Volvo (all the 90 deg were cut-downs of intended V8s)
3 throw engines are compact and light, but still have a bit of vibration
(reciprocating elements/inertia forces leave uncancelled moments at engine frequency, (primary couple), producing some vibration at the mounts, silarly the usual much smaller (rod angularity) inertia effects at twice engine frequency (secondary couple)
the Renault and Honda via F2 (production block) led to the 90 deg or 80 deg V6 in F1
the (race) 60 deg is the best package but the worst crank (uneven inertia force intervals)
the (race) 120 deg is the worst package but has ideal even inertia force intervals for higher rpm (Ferrari won F1 1961 this way)
the (race) 80-90 deg is the best overall compromise today
in production by design, not accident, there were road 6 throw 60 deg V6s eg UK and German Ford designs
(inherently heavy and long, but less vibratory, having only the (much smaller) secondary couple )
the 60 deg angle was crucial to give even firing intervals, for a refined road car (despite the disadvantage to related V4s)
Buick, then all others, usefully went to 'split-throw' crankshaft designs that combine much of the compactness of the 3 throw with the benefits of the old 6 throw, and use mostly 70-90 deg angles) ...... thanks, Mr Buick !!
split-throw crankshaft designs are not suited/pointless in F1 though ? (even compared to the 3 throw 90 deg crank)
(although split-throw is best suited to very high bore:stroke ratios in current F1)
some other bastard designs are conceivable for 2014 (worse vibration, but gains including better exhaust pulses to turbo)
(although vibration is eased by the low rpm and small bore in 2014, minimum bearing friction is very important)
we normally act as if vibration forces come only from the piston, rod, and crankshaft group
however, Keith Duckworth pointed out that vibration forces from valve motion (in race engines) were greater than those from the vibration sources normally considered