No, pyry, tomislav asks for the rpm of the wheel, not the rpms of the engine.
It depends only on the diameter of the wheel. You say a wheel with 21 inches radius, wich is around 53.3 cm.
So, the circunference of the wheel is 2*Pi*53.3 = 335.1 cm, not Pi*r as saribro used (tomislav gave the radius, not the diameter). Each turn of the wheel moves you a little over 3 meters.
Now, if you move at 400 kilometers in one hour, you have to move yourself 400/60 = 6.66 Km in a minute, right?
The number of turns per minute is 6.66 Km / 3.35 meters = 1990 turns.
So, the answer is 1990 rpm, give or take a few.
The wheel will become larger at high rpm because of the centrifugal force, but that effect is relatively slight and depends on the stiffness of the tyres. This will make a greater circumference, longer distance in one turn and slightly less rpms.
Just for fun,

at that speed, the edge of the tire moves at 6.66 Km/60 seconds = 111 meters per second.
The radius is 0.53 meters, as we said before. The centrifugal acceleration is the speed squared divided by the twice the radius. That is (111 m/s)^2 / (2*0.53 m) = 11623 m/s2. This is like 1180 G's!
Am I wrong in that last one? Over 1000 G's? Anyway, you better use high speed tyres on your first attempt...